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While acute neurological symptoms complicating lithium therapy are well recognized,persistent neurologic dysfunction is uncommon.Regardless of the duration of symptoms,neuropathological correlates of lithium toxicity are few.We report the case of a 67-year-old man who developed lithium toxicity manifested by encephalopathy and coma followed by persistent dysarthria and ataxia.Autopsy revealed neuronal loss and gliosis in the cerebellar cortex and dentate nuclei;the cerebellar white matter exhibited prominent spongy change.Persistent cerebellar syndrome may occur with lithium intoxication and should be considered in the differential diagnosis of chronic cerebellar dysfunction. |
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